And the main task of the SRG is precisely to initiate the synthesis and secretion of the anterior pituitary growth hormone.
Ibutamoren
Ibutamoren attaches to ghrelin receptors and activates them — this signals the body to start producing growth hormone.
And here's what's remarkable: at the same time, MK-677 significantly slows down somatostatin secretion, which is, hormone that suppresses the secretion of growth hormone. As a result, the surge in somatotropin is prolonged, and the peak is significantly higher than natural.
Finally, another interesting feature: ghrelin simultaneously initiates the secretion of two more hormones — cortisol and prolactin, whereas ibutamoren does not (there is still no consensus about prolactin)
Since MK-677 is considered an extremely important and promising agent — it is planned to use it both for treating growth delays in children and in anti-aging therapy — there have been many studies on it.
Dosages
How to take ibutamoren? A daily dose of 25 mg is usually used. At such a dosage, ibutamoren allows for a noticeable increase in IGF-1 concentration in the blood, indicating a significant increase in growth hormone secretion.
Essentially, 25 mg of MK-677 per day can be compared to injecting approximately 2 IU of recombinant growth hormone. This is regarding the peak value — if you take such a parameter as the area under the curve, it is approximately the same for ibutamoren as for a single injection of 3.5-4.5 IU of recombinant somatotropin per day.
Effects on the Body
As a result of ibutamoren use, a noticeable increase in "dry" muscle mass was observed. On average, about two and a half kilograms over the same 8 weeks, but the drug did not affect fat tissue, although there was an increase in the rate of metabolic processes.
Ibutamoren is also considered as a means to overcome osteoporosis. Additionally, it allows for improving sleep quality and facilitating falling asleep, increasing energy levels, and strength indicators.
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