The creators of the steroid can rightfully be considered two employees of "Searle" — Young and Pappo, who developed the idea of introducing a heteroatom into the steroid skeleton.
After several not very successful attempts, an oxygen atom was introduced into the second position (ring A), which resulted in the drug later named oxandrolone.
Oxandrolone
Oxandrolone is a derivative of dihydrotestosterone, but it does not possess any of the properties of its "parent": it has almost no androgenic or anti-estrogenic activity. The reason for this is the oxygen atom in the second position.
The first experiments on rats showed a sharp reduction in urinary nitrogen in the subjects, indicating an increase in protein synthesis by muscle fibers, but at the same time, there was virtually no noticeable growth in muscles or prostate.
On July 1, 1989, the production of American "Anavar" was discontinued, but its analogs continue to be produced to this day.
The Action of Oxandrolone
Oxandrolone is unique for its ability to greatly enhance the synthesis of creatine phosphate by muscle fibers, which can provide a significant increase in strength, almost without leading to muscle mass growth.
However, it is not possible to maintain the strength indicators at the newly reached level for a long time. The reason for this is the anti-catabolic capabilities of oxandrolone.
Oxandrolone is an outstanding anti-catabolic. It not only reduces the activity of cortisol but also suppresses its secretion.
The level of cortisol when taking oxandrolone very quickly drops to almost zero. This is both good and bad.
Good because the muscles will practically not be destroyed, which will lead to a noticeable increase in their volume.
However, this only happens if oxandrolone is used in conjunction with a sufficiently powerful anabolic steroid. Moreover, the result of lowering cortisol levels in the blood will be less water retention in the body.
Finally, at the end of the "course" of AAS, oxandrolone will not allow cortisol to "run wild" and will practically not prevent the restoration of the production of endogenous testosterone.
Bad because a sharp drop in cortisol levels will lead to a pronounced feeling of fatigue, disturbed sleep, and decreased blood pressure.
In addition, inflammatory processes will not be suppressed, so even the slightest damage to ligaments or joints can result in a serious injury. Strength indicators, of course, will drop.
Safety
Oxandrolone is considered to be a safe drug, but if approached responsibly, it cannot be called safe at all.
Yes, it can even be recommended for teenagers — use for 3-4 weeks at a dosage not exceeding 20-30 mg per day will not lead to any malfunctions in the functioning of the "HPTA" axis.
However, with longer use or exceeding the recommended dosages, oxandrolone can significantly suppress the production of endogenous testosterone.
Moreover, one must not forget about the sharp drop in cortisol levels – it makes it practically impossible to take oxandrolone for more than two weeks in a row.
Key Features
- Excellent anti-catabolic — in this regard, it surpasses any other drug in the AAS class
- Very modest anabolic capabilities
- Almost mandatory for the post-course therapy period
- Quite complex to use, so it can only be used under the supervision of a competent specialist
Usage Features
| Goal | Application | Comment |
|---|---|---|
| Muscle mass gain | can be used | optimal accompanying drug is testosterone |
| Increasing strength | can be used | although the result is temporary |
| Increasing endurance | is used | |
| Competition preparation "burning" fat | virtually mandatory | optimal accompanying AAS: testosterone, oral turinabol, stanozolol |
| Recovery after an AAS course | use is mandatory, if possible |
Recommended Dosages
The minimum dosage—which is also optimal—is 20-40 mg per day. This dosage is quite enough to suppress the synthesis and secretion of cortisol. Honestly, exceeding this dosage will not bring anything particularly good.
The maximum dosage is 80-100 mg per day. It should be noted that even with such a dosage, the effect of using oxandrolone alone is very weak, but following it for only 5-7 days leads to the manifestation of very serious side effects. The frequency of intake is 2-3 times a day
Side Effects
Oxandrolone has virtually no side effects typical of other androgens and anabolic steroids. Significantly suppresses the secretion of endogenous testosterone when following the optimal dosage.
Increasing the dosage usually leads to a noticeable suppression of the functioning of the "HPTA" axis.
| Negative impact on the liver | none |
| Negative impact on the kidneys | none |
| Negative impact on the cardiovascular system | none |
| Increased aggression | none |
| Hair loss on the head, hair growth on the body | none |
| Acne | none |
| Gynecomastia | none |
Specific Side Effects
At the same time, oxandrolone has several side effects that are unique to it:
- suppresses appetite
- causes a pronounced feeling of fatigue
- causes an exacerbation of inflammatory processes
- lowers blood pressure
- may cause sleep disturbances
All these side effects start to manifest around the 7th to 10th day of taking the drug.
Use by Women
An almost ideal drug for women: good results with a complete absence of any side effects—even those that are specific to oxandrolone. Recommended doses—10-30 mg per day
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