Tadalafil (Cialis) and Testosterone

Ivan Vlasov project creator

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Tadalafil and Testosterone

Does tadalafil increase testosterone levels? About ten years after tadalafil, known as "Cialis," appeared on the market, researchers noticed that its use resulted in a slight increase in total testosterone levels in patients.

Initially, it was believed that this was somehow related to an increase in nitric oxide (NO) levels in the blood, but it quickly became clear that NO does not affect testosterone production at all.

Indeed, "Viagra," as well as "Levitra" — another remedy for treating erectile dysfunction that appeared on the market after "Cialis," did not show any effect on testosterone levels.

The truth was finally established quite recently — in 2017. Tadalafil was found to have the properties of an aromatase inhibitor, and quite pronounced ones. And the use of aromatase inhibitors, as we remember, can increase the level of total testosterone.

Indeed, just 5 mg of tadalafil per day for three months allowed for a significant 30 percent increase in total testosterone levels.

If you need to raise testosterone levels faster (or achieve a more noticeable increase), the daily dose will have to be doubled, or even quadrupled — to 10 or 20 mg. From my point of view, 10 mg per day can be considered the optimal dose.

Drawbacks and Side Effects

However, this solution has its drawbacks. Firstly, tadalafil significantly lowers blood pressure — meaning hypotensive individuals cannot take it just like that. It also has other side effects, such as chronic nasal congestion, frequent facial flushing, or diarrhea.

Secondly, spontaneous erections at the wrong time and in the wrong place (and they will definitely happen) are not the most pleasant. Thirdly, the effectiveness of tadalafil will gradually decrease, so breaks in its use will be necessary. Finally, it is simply not the most affordable option.